Peptide Self-Assembly Methods and Protocols
This volume details methods and protocols on b-sheet assemblies and collagen. Divided into three parts chapters focus on expanding use of solid-state NMR as a powerful method to enhance structural understanding of self-assembled peptide materials, methods
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Bradley L. Nilsson Todd M. Doran Editors
Peptide Self-Assembly Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Peptide Self-Assembly Methods and Protocols
Edited by
Bradley L. Nilsson Department of Chemistry, University of Rochester, Rochester, NY, USA
Todd M. Doran Department of Medicinal Chemistry, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA
Editors Bradley L. Nilsson Department of Chemistry University of Rochester Rochester, NY, USA
Todd M. Doran Department of Medicinal Chemistry Institute for Translational Neuroscience University of Minnesota Minneapolis, MN, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7809-0 ISBN 978-1-4939-7811-3 (eBook) https://doi.org/10.1007/978-1-4939-7811-3 Library of Congress Control Number: 2018940502 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Peptide and protein self-assembly phenomena are endemic in biological systems. The regulated self-assembly and disassembly of cytoskeletal and extracellular matrix proteins form the bedrock of cellular structure and function. The dysfunctional assembly of proteins and peptides underlies a growing number of amyloid pathologies that include Alzheimer’s disease, Parkinson’s disease, and bovine spongiform encephalopathy. These disorders are marked by the aberrant self-assembly of peptides
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