Recombinant Glycoprotein Production Methods and Protocols
This volume covers a wide spectrum of techniques and approaches that are used in the upstream and downstream processing for recombinant glycoprotein production. Chapters guide the reader through state-of-art of therapeutic recombinant glycoproteins, explo
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Virgínia Picanço-Castro Kamilla Swiech Editors
Recombinant Glycoprotein Production Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Recombinant Glycoprotein Production Methods and Protocols
Edited by
Virgínia Picanço-Castro Regional Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Brazil
Kamilla Swiech School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil
Editors Virgı´nia Picanc¸o-Castro Regional Blood Center of Ribeira˜o Preto, Ribeira˜o Preto Medical School University of Sa˜o Paulo Brazil
Kamilla Swiech School of Pharmaceutical Sciences of Ribeira˜o Preto University of Sa˜o Paulo Brazil
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7311-8 ISBN 978-1-4939-7312-5 (eBook) DOI 10.1007/978-1-4939-7312-5 Library of Congress Control Number: 2017951847 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The majority of recombinant protein approved by regulatory agencies or in clinical trials have some form of post-translational modification (PTM), which can profoundly affect protein properties. Among the PTMs, glycosylation is the most common modification and one of the most important quality attributes as it can affect pharmacokinetics, immunogenicity, biological and clinical activity. For this reason, the expression system that will be used for protein production needs to be care
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