T-Cell Motility Methods and Protocols
This volume discusses the latest developments in cellular, molecular, biochemical, and imaging assays to study the biology and functions of T-cells. The chapters in this book cover topics such as LFA-1/ICAM-1 interactions in T-cell motility; using 3D-SIM
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Navin Kumar Verma Editor
T-Cell Motility Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
T-Cell Motility Methods and Protocols
Edited by
Navin Kumar Verma Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
Editor Navin Kumar Verma Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore, Singapore
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9035-1 ISBN 978-1-4939-9036-8 (eBook) https://doi.org/10.1007/978-1-4939-9036-8 Library of Congress Control Number: 2018965599 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: Human T-cells migrating via LFA-1/ICAM-1 contact: Human T-cells were stimulated to migrate by incubating on rICAM-1-coated surface for 2 h. Cells were fixed and fluorescently stained for tubulin (green), actin (red) and nuclei (blue). The image was captured by an automated microscope using 20 magnification objective. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The mobilization of T-cells into lymph nodes and tissue sites of infection or inflammation is crucial for the initiation and maintenance of an effective immune response. On the other hand, uncontrolled and persistent tissue infiltration of T-cells can lead to the development of autoimmune diseases, such as psoriasis, multiple sclerosis, and rheumatoid arthritis. This complex process of T-cell motility is precisely reg
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