Transposons and Retrotransposons Methods and Protocols
This volume covers the latest protocols designed to identify and characterize TEs in genomes, ancient or recently inserted. Additionally, this book includes a series of protocols designed to understand how host genomes act to regulate the activity of TEs,
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Jose L. Garcia-Pérez Editor
Transposons and Retrotransposons Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series editor: John M.Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Transposons and Retrotransposons Methods and Protocols
Edited by
Jose L. Garcia-Pérez GENYO (Center for Genomics and Oncological Research), Pfizer/Universidad de Granada/Junta de Andalucia, PTS Granada, Spain; Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, United Kingdom
Editor Jose L. Garcia-Pérez GENYO (Center for Genomics and Oncological Research) Pfizer/Universidad de Granada/Junta de Andalucia PTS Granada, Spain Institute of Genetics and Molecular Medicine (IGMM) University of Edinburgh United Kingdom
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3370-9 ISBN 978-1-4939-3372-3 (eBook) DOI 10.1007/978-1-4939-3372-3 Library of Congress Control Number: 2015960958 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Upon completion of the human genome and the ENCODE projects, together with “the genomics revolution” that has (and is providing) provided an enormous amount of DNA sequencing information of virtually any living creature in the world, today it is undeniable that transposable elements (TEs) have been main drivers during genome evolution. Indeed, and although often classified as “selfish DNA” or termed “junk DNA,” it is obvious that TEs manifest a tremendous impact on genome biology and its regulation. More than 25 years have passed since the seminal discovery that revealed that some TEs are still active in humans, acting
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