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TWO MIXED-LIGAND Cu(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND TREATMENT ACTIVITY ON CHILD ACUTE PANCREATITIS WITH PERITONITIS BY INHIBITING THE BACTERIAL SURVIVAL X. Cao1, J. Liu1, Y. Sun1, J. Chen1, M. Gao1, and X. Lei1*

Two mixed-ligand coordination polymers with the chemical formulae {[Cu3(Hdpc)2(tib)2(H2O)2]⋅2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)2(bimb)2⋅2H2O]n (2, H2chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)2⋅3H2O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes of E. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1β, and TNF-α. DOI: 10.1134/S0022476620080144 Keywords: coordination polymer, Cu(II) complex, child acute pancreatitis.

INTRODUCTION Acute pancreatitis is a disease in which pancreatic enzymes are activated in the pancreas due to various reasons, causing hemorrhagic edema or inflammation of pancreatic enzymes, and can be cured by non-surgical treatment [1, 2]. Mild acute pancreatitis accounts for 80% of patients with pancreatitis that has the clinical symptoms of abdominal pain, nausea and vomiting, fever, etc. [3]. Severe acute pancreatitis may produce shock, infection, peritonitis, etc., with a very high mortality rate [4]. Acute pancreatitis in children is more common in clinical practice and is prone to concurrent with infection, and the incidence rate is increasing in recent years [5]. The design and synthesis of coordination polymers (CPs) have attracted uprising research interest not only due to their structural and topological novelty but also owing to their tremendous potential applications in gas storage, chemical separations, ion exchange, microelectronics, nonlinear optics, and heterogeneous catalysis [6-10]. In general, the structural diversity of CPs often depends on many factors, such as template, metal ion, metal-ligand ratio, counteranion, pH value, and number of coordination sites provided by organic ligands [11]. Among these factors, organic ligands play an important role in controlling the diversity of CPs. In addition, the length, rigidity, coordination modes, functional groups, or substituents

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Department of Pediatric, Gansu Provincial Hospital, Lanzhou, Gansu, P. R. China; *[email protected]. Original article submitted October 10, 2019; revised November 20, 2019; accepted December 6, 2019. 0022-4766/20/6108-1281 © 2020 by Pleiades Publishing, Ltd.

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of organic ligands have consequential effects on the final structures of CPs [12]. The construction of CPs employing N and O-donor precursors leads to flexible topologies, in which