Type-1 Diabetes Methods and Protocols
The aim of this volume is to present current methodologies to predict and understand the pathogenesis of Type-1 Diabetes for clinical and non-clinical researchers. Written in the highly successful Methods in Molecular Biology series
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Kathleen M. Gillespie Editor
Type-1 Diabetes Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
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Type-1 Diabetes Methods and Protocols
Edited by
Kathleen M. Gillespie Diabetes and Metabolism Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Bristol, UK
Editor Kathleen M. Gillespie Diabetes and Metabolism Unit School of Clinical Sciences Southmead Hospital University of Bristol Bristol, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3641-0 ISBN 978-1-4939-3643-4 (eBook) DOI 10.1007/978-1-4939-3643-4 Library of Congress Control Number: 2016942863 # Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface It is now possible with great accuracy to identify individuals at risk of future type 1 diabetes, yet our understanding of the pathogenesis, the rapid increase in incidence, and the best future therapies are reliant on high-quality research utilizing the best possible methodologies. The aim of this book is to present current methodologies to predict and understand the pathogenesis of type 1 diabetes for clinical and non-clinical researchers. Bristol, UK
Kathleen M. Gillespie
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Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
v ix
Type 1 Diabetes: Current Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Aizhan Kozhakhmetov
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