Epigenome Editing Methods and Protocols
This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optim
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Albert Jeltsch Marianne G. Rots Editors
Epigenome Editing Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Epigenome Editing Methods and Protocols
Edited by
Albert Jeltsch Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart, Germany
Marianne G. Rots Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Editors Albert Jeltsch Department of Biochemistry Institute of Biochemistry and Technical Biochemistry Stuttgart, Germany
Marianne G. Rots Department of Pathology and Medical Biology University of Groningen University Medical Center Groningen Groningen, The Netherlands
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7773-4 ISBN 978-1-4939-7774-1 (eBook) https://doi.org/10.1007/978-1-4939-7774-1 Library of Congress Control Number: 2018933180 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface It has become clear in recent years that epigenetic information comprising DNA and histone protein modifications holds the access code to the genome. On one hand, this epigenetic code ensures the maintenance of cell identity, while on the other hand, the code can respond to environmental changes. Importantly, a growing list of (heritable) diseases has now been associated with epigenetic changes. Therefore, the locus-specific rewriting of epig
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