Telomeres and Telomerase Methods and Protocols
New and rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere regulation and have allowed investigators to carry out experiments using diverse model systems. For example, proteom
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Telomeres and Telomerase Methods and Protocols
Edited by
Zhou Songyang Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA
Editor Zhou Songyang, Ph.D. Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston, TX USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-091-1 e-ISBN 978-1-61779-092-8 DOI 10.1007/978-1-61779-092-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011924473 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface A gap of 40 years separates the first identification of telomeres and the discovery of the telomerase. Our knowledge of the telomerase and how telomeres are maintained, however, has undergone exponential growth since then. The telomeres are coming into sharper focus as we look deeper and wider at how telomere maintenance is critically linked to cell growth, proliferation, aging, and diseases such as cancer. For example, in the majority of human cancers, normal telomere maintenance is often bypassed. And in many human cell types, telomere erosion is thought to limit the proliferative capacity of transformed cells. This book has come at an exciting time when the 2009 Nobel Prize in Physiology or Medicine was just awarded to Drs. Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak for their pioneer work on telomeres and telomerase. New and rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere regulation and have allowed investigators to carry out experiments using diverse model systems. For example, proteomic, genomic, and molecular approaches have afforded us unprecedented insight into the complex protein interaction networks at work on the telomere chromatin and the detailed information regarding telomere dynamics in response to stress or stimuli. While the first volume of Telomeres and Telomerase: Methods and Protocols (MiMB Vol. 191) focu
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