The Urinary Proteome Methods and Protocols
Urine is one of the most easily accessible biological samples, and it provides a treasure trove of molecules essential for clinical diagnostics. In The Urinary Proteome: Methods and Protocols, expert researchers review briefly the classical urine tests th
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The Urinary Proteome Methods and Protocols
Edited by
Alex J. Rai
Methods
in
Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
The Urinary Proteome Methods and Protocols
Edited by
Alex J. Rai Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA
Editor Alex J. Rai, Ph.D. Department of Pathology & Cell Biology Columbia University Medical Center 622 West 168th Street, CHONY 2C-224 New York, NY USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-710-5 e-ISBN 978-1-60761-711-2 DOI 10.1007/978-1-60761-711-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010924744 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface This book is intended for scientific researchers, clinical laboratorians, clinical and translational scientists, and others interested in proteomics and biomarker discovery. Urine is one of the most easily accessible biological samples, and it provides a treasure trove of molecules important in clinical diagnostics. In this book, we review briefly the classical urine tests that are performed in the clinical laboratory and then delve into the state-of-the-art methods for proteomic analysis using urine specimens. The most recent advances are discussed with regard to sample preparation, data analysis, and finally methods and applications. A multitude of examples are provided including procedural details for the identification and characterization of urine biomarkers that hold potential for the diagnosis and treatment of many different disease conditions. The text is arranged so as to read systematically: introduction, sample preparation methods, application
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