Sepsis Diagnostic Methods and Protocols
This volume covers microbiological, clinical and patophysiological aspects of sepsis and also provides general overview chapters with every chapter discussing the real clinical impact of the discussed diagnostic approaches. Sepsis is a major clinical prob
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Nicasio Mancini Editor
Sepsis Diagnostic Methods and Protocols
METHODS
IN
M O L E C U L A R B I O LO G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Sepsis Diagnostic Methods and Protocols
Edited by
Nicasio Mancini University Vita-Salute San Raffaele, Milan, Italy
Editor Nicasio Mancini University Vita-Salute San Raffaele Milan, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) ISBN 978-1-4939-1775-4 ISBN 978-1-4939-1776-1 (eBook) DOI 10.1007/978-1-4939-1776-1 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 22014949861 © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
Preface Sepsis is a major clinical problem that takes an unbearable toll both on lives and economical resources. Clinical and microbiological diagnosis are therefore of pivotal importance in the management of septic patients, as it is widely recognized that an inappropriate treatment is associated, especially in the first hours, with a dramatic increase in mortality. To put it in two words: “Time matters!” When Prof. John M. Walker contacted me
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