The LINC Complex Methods and Protocols
This volume describes research methodologies and approaches used to study the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and its cellular functions. Chapters detail structural and biochemical analysis of LINC complexes, mechanical
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Gregg G. Gundersen Howard J. Worman Editors
The LINC Complex Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
The LINC Complex Methods and Protocols
Edited by
Gregg G. Gundersen Department of Pathology and Cell Biology, Columbia University, New York, NY, USA
Howard J. Worman Department of Medicine and Department of Pathology and Cell Biology, Columbia University, New York, NY, USA
Editors Gregg G. Gundersen Department of Pathology and Cell Biology Columbia University New York, NY, USA
Howard J. Worman Department of Medicine and Department of Pathology and Cell Biology Columbia University New York, NY, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8690-3 ISBN 978-1-4939-8691-0 (eBook) https://doi.org/10.1007/978-1-4939-8691-0 Library of Congress Control Number: 2018950395 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface LINCing Molecular Methodologies Across Disciplines In 2006, Didier Hodzic, Brian Burke, and colleagues coined the term LINC (linker of nucleoskeleton and cytoskeleton) complex for the assembly of Klarsicht, ANC-1, and Syne homology (KASH) domain and Sad1 and UNC-84 (SUN) domain proteins that respectively span the inner and outer nuclear membranes, connecting the nucleoskeleton to the cytoskeleton [1]. That year, we predicted that research on this complex linking the nucle
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