Teratogenicity Testing Methods and Protocols
This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both i
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Luís Félix Editor
Teratogenicity Testing Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Teratogenicity Testing Methods and Protocols
Edited by
Luís Félix Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal
Editor Luís Félix Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB) University of Trás-os-Montes e Alto Douro (UTAD) Vila Real, Portugal
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7882-3 ISBN 978-1-4939-7883-0 (eBook) https://doi.org/10.1007/978-1-4939-7883-0 Library of Congress Control Number: 2018943308 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: Image provided by Dr. Monalisa Mishra Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Teratology explores the causes, mechanisms, and patterns of exposure to naturally occurring and synthetic chemical agents and physical agents that lead to abnormal development and birth defects. The vulnerability of the developing embryo or fetus to temporary and permanent harm has long been a subject of inherent interest. However, teratology has only developed as a discipline since the 1930s, when the first report of developmental defects in a mammalian species was published. Nowadays, the Food and Drug Administration estimates tha
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